a benfotiamine-vitamin b combination in treatment of diabetic polyneuropathy

a benfotiamine-vitamin b combination in treatment of diabetic polyneuropathy

Is benfotiamine good for peripheral neuropathy?

A study of 20 patients given 400mg daily of benfotiamine showed improvement in neuropathy scores and decrease in pain complaints over a 3-week period.

Is there any benefit of vitamin B combination in reducing pain on diabetic peripheral neuropathy?

Conclusion: Vitamin B1, B6 and B12 significantly reduce the pain intensity in patients with diabetic peripheral neuropathy.

Can diabetics take vitamin B1?

Vitamin B1 – or thiamine – has long been associated with human health, including the maintenance of a healthy nervous system and improvement of cardiovascular function in the body. Scientific studies have highlighted that vitamin B1 can also help to support individuals with diabetes.

How much benfotiamine should a diabetic take?

How much benfotiamine should I take for diabetes? Healthcare providers may suggest between 150 mg and 300 mg of benfotiamine twice a day. It may decrease pain from diabetic neuropathy.

What is the use of benfotiamine tablets?

People use benfotiamine for nerve damage caused by diabetes (diabetic neuropathy). It is also used for alcohol use disorder, Alzheimer disease, arthritis, and other conditions, but there is no good scientific evidence to support most of these uses.

Is benfotiamine safe to take?

Benfotiamine is generally considered safe for most people when taken at standard doses, though long-term safety has not been studied. In clinical trials, side effects were mild and included gastrointestinal issues and skin reactions [7].

Is benfotiamine good for kidneys?

Taken together, these data suggest that benfotiamine protects the peritoneal membrane and remnant kidney in a rat model of peritoneal dialysis and uremia. Peritoneal dialysis (PD) is a well accepted alternative to hemodialysis in the treatment of end-stage renal disease.

Is vitamin B complex good for diabetic neuropathy?

It’s unclear whether taking vitamin B-12 supplements can help treat diabetic neuropathy. Some small studies have shown a lessening of pain and other abnormal sensations. However, for people who don’t have a vitamin B-12 deficiency, taking B-12 supplements for diabetic neuropathy hasn’t been shown to help.

What is methylcobalamin tablets used for?

Methylcobalamin is used to treat vitamin B12 deficiency. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells. Methylcobalamin is sometimes used in people with pernicious anemia, diabetes, and other conditions.

Is Mecobalamin and methylcobalamin same?

The terms methylcobalamin and mecobalamin are interchangeable. The extended version of mecobalamin is methylcobalamin. Vitamin B 12 is known by its scientific name. The cobalt in both of them has a methyl group connected to it.

What is the difference between benfotiamine and thiamine?

Benfotiamine is absorbed much better than water soluble thiamine salts. Maximum plasma levels of thiamine are about 5-fold higher after benfotiamine intake and the bioavailability is about 3.6 times as high as that of thiamine hydrochloride and better than that of other lipophilic thiamine derivatives.

Does B1 help neuropathy?

B vitamins for neuropathy. B vitamins are useful in treating neuropathy since they support healthy nervous system function. Peripheral neuropathy is sometimes caused by a vitamin B deficiency. Supplementation should include vitamin B1 (thiamine and benfotiamine), B6, and B12.

How is vitamin B1 metabolized?

Thiamine metabolism begins in the extracellular space, being transported by a thiamine transporter into the cell. Once in the intracellular space, thiamine is converted into thiamine pyrophosphate through the enzyme thiamin pyrophosphate kinase 1.

Does benfotiamine lower BP?

We found a marked increase in thiamine and thiamine diphosphate in all patients who received benfotiamine (Table 1, both P < 0.001). Diastolic blood pressure (DBP) was also significantly increased in the benfotiamine group (P < 0.01) and was significantly different from the change in the placebo group (P < 0.05).

Can vitamin B1 cause high blood pressure?

When the amount of vitamin B1, also known as thiamine exceeds the normal levels in the body, it can cause hypertension or high blood pressure. Similarly, when high doses of vitamin B2, usually referred to as riboflavin is taken, it can cause hypotension or low blood pressure.

Which vitamin B is best for nerve repair?

The best diet for your nerves Vitamin B1 (thiamine) provides your nerves with energy to function, while vitamin B6 relieves nerve pain and transmits nerve impulses correctly. Vitamin B12 regenerates the nerves, protecting them from damage.

Does vitamin B help with neuropathy?

B Vitamins Vitamins B-1, B-6, and B-12 have been found to be especially beneficial for treating neuropathy. Vitamin B-1, also known as thiamine, helps to reduce pain and inflammation and vitamin B-6 preserves the covering on nerve endings.

What is the latest treatment for neuropathy?

FDA approved a new capsaicin drug for treating diabetic peripheral neuropathy (DPN) of the feet in July 2020. Qutenza, from Averitas Pharma – the US subsidiary of the German pharmaceutical company Grünenthal – is a cutaneous patch that delivers prescription-strength capsaicin (8%) directly to the skin.

What is the difference between vitamin B12 and methylcobalamin?

Vitamin B12 supplements are typically derived from two sources: cyanocobalamin or methylcobalamin. While methylcobalamin contains a methyl group, cyanocobalamin contains a cyanide molecule. Cyanocobalamin is a synthetic form of vitamin B12 that’s not found in nature ( 2 ).

Is Methycobal safe for diabetic patients?

Mecobalamin also benefited nerve reflection and conduction velocity to a certain extent. No obvious side effects were found. Conclusion: Mecobalamin might be worthy of use as a safe agent in the treatment of diabetic neuropathies.