Can Hydrochlorothiazide Cause Diabetes

Which blood pressure medications lead to diabetes?

Multiple studies have demonstrated that the combination of beta-blockers and thiazide diuretics increases the risk of developing diabetes by approximately 20%.

Causes HCTZ type 2 diabetes?

Conclusions. In subjects at high risk for type 2 diabetes, HCTZ therapy is associated with the development of hepatic steatosis and impaired insulin sensitivity.

Can thiazide diuretics cause diabetes?

Long-term treatment with thiazide diuretics can result in glucose intolerance and may occasionally precipitate diabetes. Short-term metabolic studies, epidemiologic studies, and a variety of clinical trials indicate a link between the long-term use of thiazide diuretics and the development of type 2 diabetes.

Why do diuretics cause diabetes?

Diuretics can influence blood glucose levels because they inhibit glucose metabolism. When the body is unable to properly break down glucose, the glucose level in the blood rises.

What are the risks associated with taking hydrochlorothiazide?

• Back, leg, or abdominal discomfort.
• black, tar-like feces.
• the formation of blisters, peeling, or loosening of the skin.
• bloating.
• blood present in the urine or feces.
• blue lips and nail beds
• chest discomfort or tightness.
• stool colored like clay

What prescription drugs can cause diabetes?

• Corticosteroids.
• Thiazide diuretics.
• Beta-blockers.
• Antipsychotics.
• Statins.

Why is the recall of hydrochlorothiazide occurring?

Initiates Voluntary Nationwide Recall of Two (2) Lots of Quinapril and Hydrochlorothiazide Tablets USP 20mg/12.5mg Due to N-Nitroso Quinapril Impurity Detection.

Does hydrochlorothiazide raise A1c?

Hemoglobin A1c levels with hydrochlorothiazide were 7.2 +/- 1.8% (mean +/- SD), which was significantly higher than the levels of 5.9 +/- 2.3% with furosemide and 6.4 +/- 2.0% with no diuretic.

Who is not permitted to take hydrochlorothiazide?

Your physician may advise you to avoid taking hydrochlorothiazide. If you have or have ever had diabetes, asthma, gout, systemic lupus erythematosus (SLE, a chronic inflammatory condition), high cholesterol, or kidney or liver disease, you should inform your doctor.

Can diabetes caused by thiazide be reversed?

This exploratory study suggests that the impairment in glycemic control caused by the combination of a thiazide diuretic and a RASI can be reversed by switching to a regimen that does not contain a diuretic.

Does hydrochlorothiazide worsen diabetes?

It is possible that hydrochlorothiazide stimulates the liver to produce more glucose, and since beta-blockers inhibit the absorption of glucose into cells, the concurrent use of these medications can raise glucose levels sufficiently to cause diabetes.

Why do thiazide medications cause diabetes?

Current evidence suggests that thiazide-induced impairment of glucose tolerance is caused by a combination of decreased glucose-stimulated insulin release and increased peripheral insulin resistance.

Which diuretics do not raise glucose levels?

Indapamide is a vasodilator and diuretic that does not increase glucose or lipid levels in the blood.

What are the long-term consequences of diuretic use?

Among the adverse effects are increased urination and sodium loss. Diuretics can also affect potassium levels in the blood. If you take a thiazide diuretic, your potassium level can drop dangerously low (hypokalemia), which can lead to life-threatening heartbeat problems.

Can blood pressure medication raise glucose levels?

Using Beta-Blockers to Treat Arrhythmia and Anxiety. This large class of medications is used to lower blood pressure and treat a variety of other conditions, such as irregular heartbeat and anxiety, but they can also increase blood sugar levels.

What is a suitable substitute for hydrochlorothiazide?

• Zestril (lisinopril) Zestril is an ACE inhibitor, as is Lotensin, Vasotec, quinapril, Altace, fosinopril, perindopril, and captopril.
• The ARB drug class includes Diovan (valsartan).
• Norvasc (amlodipine) (amlodipine)
• Lasix (furosemide) (furosemide)
• Aldactone (spironolactone) (spironolactone)

When should hydrochlorothiazide be discontinued?

You might require blood pressure medication for the remainder of your life. Do not abruptly stop taking hydrochlorothiazide and metoprolol, even if you are feeling well. Stopping abruptly may result in life-threatening heart conditions.

Is hydrochlorothiazide a medication with a high risk?

Hydrochlorothiazide (HCTZ) is a thiazide-type diuretic that has been utilized in clinical settings for over fifty years. The drug has been widely used around the world to treat hypertension and is relatively safe.

Which medications can induce type 2 diabetes?

Important adverse effects include hyperglycemia and diabetes. Alpelisib, antipsychotics, and antiretrovirals are among the medications that can induce hyperglycemia and diabetes; therefore, proper management strategies are required when they are prescribed.

What causes diabetes in reality?

The exact cause of the vast majority of diabetes types is unknown. In all circumstances, sugar accumulates in the bloodstream. This is because the pancreas produces insufficient insulin. Both types of diabetes can be brought on by a combination of genetic and environmental factors.

Which drug should people with diabetes avoid?

Some antibiotics, such as rifampin and isoniazid. Several medications for high blood pressure, including calcium channel blockers, beta-blockers, and thiazide diuretics. Corticosteroids. Estrogen.

Is hydrochlorothiazide kidney toxic?

Hydrochlorothiazide, furosemide, and spironolactone are popular diuretics. They increase the likelihood of acute kidney injury.

Can hydrochlorothiazide cause cancer?

Recent epidemiological research from Denmark has shown that HCTZ use is strongly associated with an increased risk of lip cancer and non-melanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC).

Is hydrochlorothiazide associated with weight gain?

Hydrochlorothiazide (Microzide) functions to eliminate excess fluid from the body. By eliminating this fluid, it is possible to lose weight.

Why is sun exposure prohibited while taking hydrochlorothiazide?

Some individuals taking this medication may become more photosensitive than usual. Even brief exposure to sunlight can cause severe sunburn; skin rash, redness, itching, or discoloration; and vision changes.